The Europa League has been slightly streamlined for the 2021/22 season, meaning it is even more competitive than ever as clubs seek a place in the Champions League.
Last season, it was La Liga outfit Villarreal who were triumphant as they defeated Ole Gunnar Solskjaer's Manchester United in a penalty shootout.
Several clubs will harbour ambitions of the same going into the first round of group games, which take place on September 16.
Europa League Outright Winner Betting Odds
Currently, two clubs share the favourites tag in the betting in Leicester City and Napoli, both of whom are available at 14/1.
The Foxes narrowly missed out on Champions League football for a second year running at the end of last season and will hope to give the Europa League a better go of things this season than last, when they were dumped out in the last 32 by Slavia Prague.
Napoli have a better record, reaching a quarter-final and semi-final in the last six years.
West Ham are next on the list at 16/1 with David Moyes continuing his renaissance at the club, while Bayer Leverkusen, Lazio and Real Sociedad are all 20/1.
Europa League Group Stage Predictions
West Ham to win Group H - BET NOW
All over the park, West Ham are solid and they will fancy their chances of going far, even if this is their first tilt at a European competition for five years.
Defensively, they are very solid and the addition of Kurt Zouma, who possesses plenty of European experience will only strengthen them.
Nikola Vlasic can also provide some of that continental magic after signing from CSKA Moscow, while in Michail Antonio the Hammers have a forward bursting with confidence after his exceptional start to the season, which has already yielded four goals in three matches.
Marseille to win Group E - BET NOW
Group E is certainly a tough one to call with Lazio, Galatasaray and Lokomotiv Moscow making it potentially one of the most hostile groups in the history of the competition.
But Marseille have previous form in this competition, having reached the final in 2018 before losing to Diego Simeone's Atletico Madrid.
In their run to the final three years ago, they didn't lose a single game and will be hoping for more of the same.
Europa League Winner Prediction
Napoli to Win - BET NOW
After a turbulent few years, Napoli appear to be getting back on track and the appointment of Luciano Spalletti has certainly helped that.
The former Roma boss has returned refreshed from a two-year hiatus and has already guided his new club to two wins from two in their opening Serie A fixtures.
In the summer transfer window, they managed to hold onto star assets Lorenzo Insigne and Kalidou Koulibaly despite reported interest from elsewhere.
Spalletti has won trophies with Roma and Zenit St Petersburg and could be the man to guide Napoli to glory.
2021/22 Europa League Betting Tips
1. West Ham to win Group H - BET NOW
2. Marseille to win Group E - BET NOW
3. Napoli to Win - BET NOW
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2021/22 Europa League Outright Frequently Asked Questions
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West Ham to win Group H.A