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Manchester City host Tottenham Hotspur on Wednesday night at the Etihad Stadium down a goal. Heung-min Son's 79th-minute goal was the difference between the two sides in the first leg. However, Manchester City will be confident they can overcome the deficit having defeated Crystal Palace 3-1 on Sunday.

Tottenham Hotspur rode their luck at times against Manchester City in the first leg as goalkeeper Hugo Lloris saved a Sergio Aguero first-half penalty. With injuries mounting again, can Mauricio Pochettino's team progress to the Champions League semifinals?

Manchester City v Tottenham Hotspur Betting Odds

Despite losing the first leg last week, leading sportsbook expect Manchester City to win. Manchester City looked very strong against Crystal Palace at the weekend and were never in trouble. The Cityzens won't have such a comfortable game against Tottenham Hotspur, however.

Tottenham Hotspur thrashed Huddersfield 4-0 at the weekend. Victor Wanyama was on target for a rare goal while Lucas Moura scored a hat-trick. Pochettino rotated his thin squad to give key players a rest ahead of their visit to the Etihad.

Manchester City are strong favourites for a victory within 90 minutes at best-price odds of 1/3. Tottenham Hotspur go into the fixture at odds of 10/1 to win at the Etihad.

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Manchester City v Tottenham Hotspur Team News

Harry Kane will not play on Wednesday night, and most likely, not again this term. The striker rolled his ankle in the first leg and was forced off having damaged ligaments once more. Dele Alli could also miss the fixture. He injured his wrist and hand late in the first leg. Meanwhile, midfielder Harry Winks is a doubt for Spurs as well.

In contrast, Pep Guardiola will have all of his stars fit and ready for Tottenham's visit. Defensive midfielder Fernandinho was rested on Sunday as he is suffering from a short-term knock. He is expected to play some part for Manchester City. The Brazilian defensive midfielder has been crucial as the pivot to the team's midfield base. 

Manchester City v Tottenham Hotspur Betting Tips

Sergio Aguero to score anytime @ 20/23 - BET NOW

Aguero's penalty miss in the first leg changed the tie. Had he converted, Tottenham Hotspur would have been chasing the game and Manchester City may have added further goals. Aguero will be hungry to make amends in the second leg. 

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The first leg was close and cagey with neither side finding a way through for most of the match. Both Guardiola and Pochettino are expert tacticians and they will make it difficult for the other side to score. 

Manchester City v Tottenham Hotspur Prediction

Manchester City to win 2-0 @ 7/1 - BET NOW

Tottenham Hotspurs' injury problems have once again reared its ugly head. Kane and Alli are Tottenham's two most important players, but at least one of them will play no part in the second leg. Their absence takes two goal-threats out of Pochettino's starting XI. 

Manchester City are at home and with their supporters behind them should have no difficulty overturning the tie. It is worth noting, Tottenham Hotspur need an away goal to turn the tie on its head. A Spurs goal would force Manchester City to score three times. 

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