For the second straight season, Inter Milan and Real Madrid will play in the Champions League group stage. The two rivals are joined by Shakhtar Donetsk (again for the second straight season) and Sheriff Tiraspol. Ahead of kick off at San Siro, Inter Milan and Real Madrid will be expected to go through Group D into the knockout stage of the Champions League tournament. However, Shakhtar Donetsk will aim for another solid season in the Champions League after winning home and away versus Real Madrid in 2020-21.

Inter Milan vs Real Madrid Match Preview

Inter Milan go into the fixture on Wednesday at San Siro unbeaten in three straight games to start the new campaign. Despite losing their coach and having a fire sale that saw Romelu Lukaku join Chelsea, Inter Milan have played well with the replacement recruits. The Nerazzurri have taken seven points from nine in Serie A.

Real Madrid are joint leaders in La Liga having taken 10 points from 12 points available this season. Los Blancos have started well despite shaking up the team’s defence in the offseason. Real Madrid won both Champions League group fixtures against Inter Milan last season. Can they make it three straight matches versus the Nerazzurri with wins?

Inter Milan vs Real Madrid Betting Odds



Last season’s Champions League group stage fixtures between Inter Milan and Real Madrid were competitive. The team’s game in Madrid finished 3-2 in favour of Los Blancos. Karim Benzema, Sergio Ramos, and Rodrygo got on the scoresheet for Real Madrid. Lautaro Martinez and Ivan Perisic got the goals for Inter Milan, but Rodrygo’s late goal sealed the win for Los Blancos.


The reverse group stage fixture finished 2-0 in favour of Real Madrid. An Eden Hazard penalty and Achraf Hakimi own goal gave Real Madrid the victory. Inter Milan played with 10 men for nearly an hour of the match after Arturo Vidal’s first half sending off.

Leading bookies’ best betting odds on an Inter Milan win are at 29/20. Champions League games between these sides have been few and far between. This will be just their third Champions League match in recent time.

Real Madrid’s best betting odds to win at full-time against Inter Milan are at 15/8. Carlo Ancelotti’s team have outscored opponents 13-6 this season with one clean sheet. Inter Milan have outscored opponents 9-3. They too have had one clean sheet. The Nerazzurri won just once in the Champions League group stage last season.

Inter Milan vs Real Madrid Team News

Inter Milan defender Alessandro Bastoni is unlikely to be fit for Wednesday's match. Bastoni is nursing a thigh injury he sustained during the international break. Federico Dimarco, Stefan De Vrij and Milan Skriniar should play as a back three with Matteo Darmian and Ivan Perisic as wing-backs.

Simone Inzaghi should play a similar team to the one that featured against Sampdoria at the weekend. The Nerazzurri couldn’t hold a halftime 2-1 lead against Samp and drew 2-2. Central midfielders Nicolo Barella, Marcelo Brozovic and Hakan Calhanoglu should take up the three positions in the middle of the park. Edin Dzeko should start in attack with Lautaro Martinez next to him.

Ancelotti may be without up to seven first-team players for matchday 1 of the Champions League group stage. Gareth Bale, David Alaba, Toni Kroos and Luka Jovic all missed the team’s 5-2 win over Celta Vigo. Bale (hamstring), Alaba (muscle overload), Kroos (groin) and Jovic (gastroenteritis) will be monitored up to the time Real Madrid leave for Italy.

Left-back Ferland Mendy and midfielder Dani Ceballos are both unavailable for the game. Left-back Marcelo is ruled out following an injury in training this week. He will be replaced by 20-year-old Miguel Gutierrez.

Inter Milan vs Real Madrid H2H

Real Madrid won both matches in the Champions League between these teams last season. They went o San Siro and won 2-0 thanks to a penalty and an own goal. Meanwhile, Arturo Vidal was sent off in the opening half. Inter Milan should be much better on the night following their fire sale in the summer.

The Nerazzurri weren’t expected to be Serie A Scudetto contenders following the transfers of key players and departure of Antonio Conte. Yet, the Nerazzurri have looked just as strong to open up the season. Likewise, Real Madrid weren’t expected to be as strong as they are following the departures of Raphael Varane and Sergio Ramos.

Inter Milan vs Real Madrid Prediction

Both teams to score goals: YES @ 4/7 - BET NOW



Two of Inter Milan’s games in 2021-22 have finished with both teams scoring goals. Three of Real Madrid’s four games in 2021-22 have ended with both teams finding the back of the net. Based on these trends, our betting tips prediction is for both teams to score in an exciting match on Wednesday night at San Siro.


Karim Benzema to score anytime @ 8/5 - BET NOW



Karim Benzema has already scored five goals in four La Liga matches. He has added four goals for Real Madrid during that same time period. The team rely heavily on Benzema. If the Frenchman went down with an injury, Real Madrid could struggle in all competitions. Benzema averages a goal every 72 minutes in La Liga. Our betting tips prediction is for the former Lyon striker to bag another goal.


Over 2.5 goals scored @ 8/11 - BET NOW



These teams played out a 3-2 Real Madrid win in last season’s Champions League group stage. Our betting tips prediction is for these sides to do it once more on matchday 1 of the competition this campaign. All three of Inter Milan’s games this season have seen over 2.5 goals scored. The Nerazzurri have outscored opponents 9-3. Three of Real Madrid’s four games in La Liga have finished with over 2.5 goals scored.


Inter Milan should be much better this season in the Champions League. Keep in mind that last season there were no fans in attendance. Supporters should make a big difference and Inter Milan should get a win or draw on Wednesday night at home.