Still with hope of winning the Six Nations title, Ireland will be looking to make sure they do their job against Scotland before the tournament concludes on Super Saturday with France against England.
The Irish have an impressive record against the Scots in recent years and will be eager to make sure they get the win to pile the pressure on France for the game in Paris.
Ireland vs Scotland Betting Odds
Scotland didn't lose a game to Ireland in their 12 meetings between 1989 and 1999 with the Scots winning 11 and drawing once.
The turn of the millenia seemed to change everything and since the tournament became the Six Nations in 2000 the Irish have dominated this fixture.
In their 22 Six Nations meetings to date, Ireland have won 18 of them, one of the reasons why they are firm favourites at 1/7 to win in Dublin on Saturday.
Scotland have proved on their day they can beat anyone but they will have to produce their performance of the tournament to win this weekend.
Gregor Townsend's side can be backed at 13/2 to win, while the first draw between these sides since 1994 is available at 50/1.
Ireland vs Scotland Team News
Ireland have made three changes to the side that beat England at Twickenham last time out, with Ulster captain Iain Henderson making his first start of this year's tournament.
Meanwhile, wing Mack Hansen and number eight Jack Conan also come into the side for Andrew Conway and Peter O'Mahony respectively.
As for Scotland, there were plenty of eyebrows raised when fly-half Finn Russell was missing from the starting lineup.
The Racing 92 playmaker has had a below-par tournament by his high standards but was still expected to start in Dublin.
Edinburgh utility back Blair Kinghorn has been given the No.10 jersey having impressed at standoff for his club side this season, while Russell will look to make an impact off the bench.
Lock Jonny Gray replaces his Exeter Chiefs teammate Sam Skinner in the only other change from last week's win in Rome against Italy.
Ireland vs Scotland Where To Watch on TV
ITV will have live coverage of Ireland's clash against Scotland on Saturday, March 19th. Coverage begins at 16:00, with the game kicking off at 16:45.
Ireland vs Scotland Prediction
Ireland to win by 11-20 - BET NOW
Ireland have the structured game and physical presence at the breakdown to overpower Scotland in Dublin.
The Scots do have some attacking threats around the park and they should have some moments where they can get the Irish on the back foot.
However over the course of 80 minutes, Ireland should just have too much for Scotland and can earn the win to keep their Six Nations title hopes alive.
Darcy Graham Anytime Tryscorer - BET NOW
With tries against Wales and Italy already in the tournament this year, keep an eye out for Scotland winger Darcy Graham in the anytime tryscorer market.
The 'Prince of Hawick' might not be the largest but his elusive running and searing pace can cause Ireland problems.
It would be no surprise to see Graham add to his try tally this weekend at the Aviva Stadium.
Ireland vs Scotland Betting Tips
1. Ireland to win by 11-20 - BET NOW
2. Darcy Graham Anytime Tryscorer - BET NOW
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Six Nations 2022: Ireland vs Scotland Betting Tips
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Six Nations 2022: Ireland vs Scotland Frequently Asked Questions
When is Ireland vs Scotland?
Saturday, March 19th.A
What time does Ireland vs Scotland kick off?
Where is Ireland vs Scotland being played?
Who are the favourites?
Ireland are the 1/7 favourites.A
What is our recommended bet?
Ireland 11-20 Winning Margin.A