Barcelona have had plenty of problems, on and off the field, in recent times, and Real Betis can pile further misery on the Catalan giants when they clash at the Nou Camp on Saturday.
Barcelona made it three wins from three in the Champions League on Wednesday, although they were less than convincing as they beat Dynamo Kiev on home soil.
Getting results in Europe has proven easier than picking up victories in La Liga and questions are already being asked of Ronald Koeman following his appointment over the summer.
They head into Saturday's game at home to Real Betis sitting 12th and with just two wins from their opening six matches.
Indeed, the Blaugrana have failed to win any of their last four in the league, losing two and drawing two, and Betis could earn just a second La Liga triumph at the Nou Camp since 1998.
Betis have been an all-or-nothing side this term, winning four and losing four in the Spanish top flight, but it's worth noting that two of those defeats have come at the hands of Real Madrid and Atletico Madrid.
Barcelona vs Real Betis Betting Odds
Real Betis to win - BET NOW
Despite their struggles this season, Barcelona are still heavy 2/5 favourites to win Saturday's encounter, largely due to the fact that they play at home.
But even the Nou Camp, which has been a fortess over recent years, hasn't given Barcelona an edge with Osasuna and Real Madrid picking up victories there in the last four games.
Prior to that defeat against Osasuna in the penultimate game last season, Barcelona were unbeaten in 30 home fixtures - dating back to November 11, 2018 when they lost 4-3 to Betis.
The visitors can be backed at a very attractive 7/1 to pick up a second win in their last three visits as they look to end the weekend in the European positions.
A draw looks unlikely considering Betis' record in eight league outings this term, while it's also worth noting that this fixture when played a the Nou Camp hasn't seen a draw since 2007, but that outcome is available at 9/2.
Barcelona vs Real Betis Team News
Ronald Araujo broke into the Barca first team late last season and has been involved in the early stages of 2020-21. However, the defender looks set to miss out after sustaining a hamstring injury against Juventus last month.
More crucially, Philippe Coutinho is set to be sidelined once again as he continues to nurse a hamstring issue which will keep him out until after the international break.
Samuel Umtiti is a long-term absentee and hasn't featured so far this season as he battles with ongoing knee issues.
Real Betis are still without Victor Camarasa due to a knee injury, while Andres Guardado, Juanmi and Sidnei are set to be assessed ahead of kick off.
Barcelona vs Real Betis Prediction
Both teams to score - BET NOW
Barcelona have picked up just one clean sheet in five home fixtures across all competitions this season and improving on that record looks unlikely this weekend.
Indeed, both teams have found the back of the net in the last four games to have taken place at the Nou Camp, while that bet has also landed in each of the last two editions of this fixture.
Despite the Balugrana's struggles at the back this term, they are expected to be offered opportunities by Betis.
Manuel Pellegrini's side, who sit seventh, have conceded more goals than any club in the top 11 and Barcelona's impressive attacking options should give them the tools to find a way through.
Barcelona vs Real Betis Tips
Christian Tello anytime scorer - BET NOW
Tello failed to make the grade at Barcelona after graduating from the club's famous academy system but he has proven to be a success elsewhere.
After developing with Porto and Fiorentina, Tello landed at Betis in 2017 and he has already bagged four goals in the league this term.
Players often tend to raise their game when taking on former employers and Tello will certainly be out to prove a point when he returns to Catalonia on Saturday.
Barcelona v Real Betis Betting Tips
Barcelona v Real Betis Frequently Asked Questions
Which ground will Barcelona vs Real Betis be played at?
The game will take place at the Nou Camp.A
Where can I watch Barcelona vs Real Betis?
The match will be on LaLigaTV.A
What is our recommended bet?
Both teams to score.A
What is kick-off time for Barcelona vs Real Betis?
Saturday's fixture gets underway at 15:15.A